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SYLLABUS
INSTRUCTOR: Name:
Dr. Cheryl D. Davis
Email: cheryl.davis@wku.edu |
MEETINGS:Lecture M W
12:20-1:20pm TCNW 203
Lab M or W 1:30-3:30pm TCNW 134
TEXTBOOK: Kuby Immunology (Fourth Edition by Richard A. Goldsby (Amherst College),Thomas J. Kindt (National Institutes of Allergy and Infectious Disease), and Barbara Osborne (U. of Massachusetts, Amherst)
COURSE DESCRIPTION: An introductory study of the mammalian immune system
EXAMS: Three 100pt exams and three 20pt quizzes offering a total of 360 points will be given as indicated in the course schedule. In addition, a term paper (100 points) will be required of all students and should contain a title page and abstract (250 word limit), the text (using sub-headings to logical organize information), and a reference section. The paper should be at least 10 pages but should not exceed a total of 15 pages. A minimum of 6 primary references will be required.
Exam #1
100pts
Exam #2 100pts
Exam #3 100pts
Quizzes 60pts
Term Paper 100pts
Laboratory 240pts
Total
700pts
The laboratory grade will be based upon:
- 4-Take Home Laboratory Assignments - 50 points each
- Attendance: 40pts (10 points will be deducted for the first unexcused absence, an additional 15 points will be deducted for each additional unexcused absence.
Make-up quizzes and exams will only be given for situations beyond your control.
|
TENTATIVE LECTURE SCHEDULE |
| DATE | TOPIC | TEXT |
| 1/14 | Introduction / Innate Immunity | Chapter 1 (p. 10-19) |
| 1/16 | Innate Immunity /Inflammatory Process | Chapter 15 (p. 379-387) |
| 1/21 | Martin Luther King Holiday | . |
| 1/23 | Inflammation / Cells of the Immune System | Chapter 2 (p.35-46) |
| 1/28 | Cells of the Immune System | Chapter 2 (p.35-46) |
| 1/30 | Hematopoiesis (Quiz #1) | Chapter 2 (p. 27-34) |
| 2/4 | Lymphoid Organs | Chapter 2 (p. 47-57) |
| 2/6 | Lymphoid Organs II | Chapter 2 (p. 47-57) |
| 2/11 | Antigens | Chapter 3 (p. 63-77) |
| 2/13 | Immunoglobulins | Chapter 4 (p. 83-94) |
| 2/18 | Exam #1 | |
| 2/20 | Immunoglobulins (cont.) | Chapter 4 (p. 95-104) |
| 2/25 | Immunoglobulin Genes | Chapter 5 (p.115-121) |
| 2/27 | Immunoglobulin Genes | Chapter 5 (p.122-132) |
| 3/4 | Regulation
of Ig Gene Expression (Paper Titles / 4 Primary References DUE) |
Chapter 5 (p.133-138) |
| 3/6 | Regulation
Ig Gene Expresson / MHC (Quiz #2) |
Chapter 7 (p.173-180) |
| 3/11 | Major Histocompatability Complex | Chapter 7 (p.181-193) |
| 3/13 | Antigen Processing and Presentation | Chapter 8 (p.201-208) |
| 3/18-3/20 | Spring Break | |
| 3/25 | Antigen Processing and Presentation | Chapter 8 (p.209-212) |
| 3/27 | T Cell Receptor | Chapter 9 (p.215-234) |
| 4/1 | Exam #2 | |
| 4/3 | T Cell Receptor | Chapter 9 (p.215-234) |
| 4/8 | T Cell Maturation | Chapter 10 (p.239-248) |
| 4/10 | No Lecture / Papers DUE | |
| 4/15 | T Cell Activation, Differentiation | Chapter 10 (p.249-261) |
| 4/17 | B Cell Activation & Differentiation | Chapter 11 (p.269-279) |
| 4/22 | Complement (Quiz #3) | Chapter 13 (p. 329-346) |
| 4/24 | Cytokines | Chapter 12 (p.303-318) |
| 4/29 | Cytokines | Chapter 12 (p.318-322) |
| 5/1 | Cell Mediated Immunity | Chapter 14 (p. 351-368) |
| 5/6 | Exam #3 (1:00 to 3:00pm) | |
| Sample
Quiz 1 Sample Exam 1 Sample Exam 2 Sample Exam 3 Sample Exam 4 |
Sample Term Paper (MS Word)
| Suggested Term Paper Topics: |
Mast Cells (very interesting
leucocyte with diverse immunological functions)
The Role of Toll-Like Receptors in the Immune System
T reg Lymphocytes (regulatory T lymphocytes)
New Immunotherapeutic Approaches to the Treatment of Allergy / Asthma
Clinical Uses of Hematopoietic Stem Cells
Chimeric and Hybrid Monoclonal Antibodies
Role of the Major Histocompatability Complex in Mate Choice
Bacterial Superantigens DNA vaccines / Recombinant Vector Vaccines
Therapeutic Uses of Cytokines (could focus on Allergy, Autoimmune Disease,
or Infertility)
Cytokine Regulation during Pregnancy
Role of gd T cells During Pregnancy
Role of NK cells During Pregnancy
Lymphocyte Migration and Homing
Experimental Therapeutic Approaches to Autoimmune Disease
Role of Fas/ FasL - Mediated Apoptosis in Immunological Privilege (brain,
eye, trophoblast, etc.)
Tumor Evasion of Immune Response
Cancer Immunotherapy
Exogenous Antigen Presentation by MHC Class I Molecules
Role of Microbial Heat Shock Proteins in the Etiology of Autoimmune Disease
Effects of Dietary Antioxidants on the Function of The Immune System
Recent Advances in Transplantation Immunology
Use of Gene-Targeted Knock Out Mice in Immunological Research
Somatic Hypermutation of Immunoglobulin Genes
Mechanisms of Heavy Class Switching
Properties of Memory Lymphocytes
Regulation of the Classical Pathway of Complement
Regulation of the Alternative Pathway of Complement
| Online Lecture outlines, use with caution 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 |