Activity


Expression of a protein is energetically expensive.  How many high energy phosphodiester bonds are used to make an average sized prokaryotic protein that is 66,000 molecular weight?

Average molecular weight of an amino acid is 110.
In translation
    1 GTP -> GDP for initiation = (1 high energy bonds)
    1 ATP -> AMP for each amino acid attached to tRNA = (2 high energy bonds)
    1 GTP -> GDP for each tRNA attached to ribosome = (1 high energy bonds)
    1 GTP -> GDP for each translocation of the ribosome = (1 high energy bonds)
Three bases transcribed per amino acid
In transcription
    1 P-P released per base incorporated, which is further broken down into 2 P. = (2 high energy bonds)

 

If there are 32 ATPs produced, from ADP + P, for each glucose molecule metabolized, = (32 high energy bonds), how many glucose must be metabolized to provide enough energy to produce one average sized protein?