Signal-Mediated Transport through Nuclear Pore Complexes

(Lodish et al., 2000, Section 11.4

The nucleus has a double membrane with pores that are about 30x bigger than a ribosome.
Molecules are transported out of and into the Nucleus based on intrinsic signals.
mRNA are transported only after splicing is completed

Model for passage of mRNPs through the nuclear pore complex (Fig. 11.31).
Proposed mechanism for hnRNP protein mediated export of mRNA from the nucleus (Fig. 11.34).

Proposed mechanism for the transport of "cargo" proteins containing a leucine-righ nuclear-export signal (NES) from the nucleus to the cytosol (Fig. 11.33).

Proposed mechanism for the transport of "cargo" proteins containing nuclear-localization signal (NLS) from the cytoplasm to the nucleus (Fig. 11.37).

The transport of mRNA from the nucleus to the cytoplasm can be regulated (Fig. 11.38).

Activity

Quiz

References:
Lodish, H., Berk, A., Zipursky, S.L., Matsudaira, P., Baltimore, D., Darnell, J., 2000, Molecular Cell Biology, 4th Ed., W.H. Freeman and Company, NY, New York. ISBN 0-7167-3136-3.