Lecture 3

In-class project

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Q: What would the charges be on an amino acid at pH = 1, or pH = 12?

 

 

 

Q: Which amino acid R-groups are able to participate in: 1) H-bonding, 2) Hydrophobic interactions, 3) Disulfide bonding, 4) Ring stacking, 5) Ionic bonding, 6) van der Waals interactions?

Amino acid

Abbrev.

H-bonding

Hydrophobic

Disulfide

Ring stacking

Ionic bonding

Van der Waals

Alanine

A

 

 

 

 

 

 

Cysteine

C

 

 

 

 

 

 

Aspartic Acid

D

 

 

 

 

 

 

Glutamic Acid

E

 

 

 

 

 

 

Phenylalanine

F

 

 

 

 

 

 

Glycine

G

 

 

 

 

 

 

Histidine

H

 

 

 

 

 

 

Isoleucine

I

 

 

 

 

 

 

Lysine

K

 

 

 

 

 

 

Leucine

L

 

 

 

 

 

 

Methionine

M

 

 

 

 

 

 

Asparagine

N

 

 

 

 

 

 

Proline

P

 

 

 

 

 

 

Glutamine

Q

 

 

 

 

 

 

Arginine

R

 

 

 

 

 

 

Serine

S

 

 

 

 

 

 

Threonine

T

 

 

 

 

 

 

Valine

V

 

 

 

 

 

 

Tryptophan

W

 

 

 

 

 

 

Tyrosine

Y

 

 

 

 

 

 

 

 

Q: Are all combinations of psi and phi angles possible?  Explain.