Advanced Molecular Genetics-Biology 566 Lambda regulation
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Central Dogma

What is the "Central Dogma" of living organisms?

Project 1:

Draw a diagram of the central dogma and illustrate the points in the diagram where regulation of the flow of information is controlled. Use examples if necessary.

Enzymes

Enzymes catalyze the chemical reactions in cells.

Life depends on the specificity of enzymes.

Enzymes typically catalyze just one reaction.

Project 2:

In pathways of regulation, such as phosphorylation of tyrosine by a specific kinase, only specific tyrosines are phosphorylated. How do specific tyrosine kinases distinguish one tyrosine from another?

Demonstration: A tale of two blinds.

What does tethering do to the rate of reaction?

For methylation of DNA in nucleus, enzymes can be free in the nucleoplasm or associated non-specifically with the DNA by a basic domain on the enzyme.
Which form, would you expect, has the greatest activity in methylating DNA?

Do interaction always need to be direct? What are some other alternatives?

Role of "Recruitment".

How can enzymes take on new activities, or evolve?

How closely related are the diversity of organisms?

Do they differ in size of their genome and number of genes?

What is the relationship of genes to genome size?

Why is it that in complex organisms there is not a great amplification of genes?

How are complex regulations controlled?

This course will explore gene regulation by allostery, signal transduction, silencing, chromatin modification and developmental signaling.