Advanced Molecular Genetics-Biology 566

Effector enzymes Coupled to GTP Binding Proteins
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Adenylate Cyclase

There are a number of adenylate cyclases that share 40-60% identity and all function to form cAMP from ATP.

Early assays of adenylate cyclase ceased to work as more highly purified ATP was used. This led to the link to G-protein activation.

 

cAMP

 

Organization and structure of adenylate cyclase.

 

Adenylyl cyclases

 

Activation and inhibition of adenylyl cyclases is tissue specific for the different isoforms of the enzyme.

Activation of Adenylyl cyclases

Integration of multiple pathways that alter the activity of adenylyl cyclase.

Adenylyl cyclase isoforms and patterns of activation and inhibition

 

Phospholipase C

 

Phospholipases cleave specific phospholippid ester bonds

 

PI derivatives

 

Organization of phospholipase C

 

Membrane-associated PLC

 

 

 

Created 2004 by CA Rinehart for CLASSROOM USE ONLY. References for source material used here may be found in References .

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