Advanced Molecular Genetics-Biology 566 Lambda regulation
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More regulated recruitment by lambda phage

Life cycle of lambda can exist as a lysogen or proceed through the lytic cycle.

Figure 1.10 Lambda propagation alternatives.

Lambda Genome

Regulation of Lambda phage and the decision between lytic and lysogenic growth.

How does lambda decide whether it will go through the lytic or lysogenic cycle?

What physiological clues from the cell influence this decision?

Figures 1.11-12. Lambda right promoter features

Figure 1.13-14. Lambda right promoter regulation by CI and cro.

The Pre and Prm promoters are weak promoters.

TTGACA TATAAT      TTGACA TATAAT

CAAACA TTCATA      GTTTGT AAGTAT

The Pr is a strong promoter

TTGACA TATAAT

TTGACT GATAAT

Fig. 1.15-16. Cooperative binding of CI repressor.

Fig. 1.17. The functional patches on lambda repressor.

Figure 1.18 Synergistic activation of the lambda CI repressor gene by CAP.

Antitermination strategies (overhead).