Advanced Molecular Genetics-Biology 566 Syllabus
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Topic Schedule

Date	Topic	Reading
Jan. 13	Introduction, Central Dogma	Review
15	Prokaryotic b-galactosidase regulation	G&S 1-26, 177 - 181
20	Prokaryotic - Lambda Phage gene expression	G&S 26-42
22	Prokaryotic - Polymerase Activation, Promoter Activation, Silencing	G&S 42-57
27	Yeast regulation, Gal	G&S 59-92
29	Yeast silencing	G&S 92-114, Ann. Rev. Biochem. 2003. 72:481–516
Feb. 3	Recruiting	G&S 92-115
4	GENOMIC IMPRINTING: Intricacies of Epigenetic Regulation inClusters	Annu. Rev. Cell Dev. Biol.2003.19:237–59
10	NATURAL SELECTION AND THE EVOLUTION OF GENOME IMPRINTING	Annu. Rev.Genet.2003.37:349–70
12	XIST RNA AND THE MECHANISMOF XCHROMOSOME INACTIVATION	Annu. Rev.Genet.2002.36:233–78
17	THE DYNAMICS OF CHROMOSOME ORGANIZATION AND GENE REGULATION	Annu. Rev. Biochem. 2003. 72:573–608
29	GROWING OLD: Metabolic Control and YeastAging GENETICS OF AGING IN THE FRUIT FLY, DROSOPHILA MELANOGASTER	Annu. Rev. Microbiol.2002.56:769–92, Annu. Rev.Genet.2003.37:329–48
24	CONTROL OF DEVELOPMENTAL TIMING BY MICRORNAS AND THEIR TARGETS	Annu. Rev. Cell Dev.Biol.2002.18:495–513 Science 2 Jan; 303:83-86
26	Exam 1
Mar. 2	THE GENETICS OF RNA SILENCING	Annu. Rev.Genet.2002.36:489–519
4	Signal Transduction	TBA
9	"	"
11	"	"
16	"	"
18	"	"
23	Spring Break
25	Spring Break
29	HOW DO CELLS KNOW WHAT THEY WANT TO BE WHEN THEY GROW UP? Lessons from Epidermal Patterning in Arabidopsis	Annu. Rev. PlantBiol.2003.54:403–30
31	Stem Cells	Science Sep12'02; 298:601-604, 298:597-600
Apr. 1	Presentation topics and a copy of the journal articles due to instructor.	TBA
6	Stem Cells Cont.	TBA
8	Exam 2
13	Student Presentations
15	Student Presentations
20	Student Presentations
22	Student Presentations
27	Student Presentations
29	Student Presentations
May 4	Final Exam, 8-10 AM

Prerequisites: Biology 495 or consent of instructor.

Consideration of the molecular mechanisms for gene expression and regulation. 3 hr. credit.

Instructor: Claire Rinehart Office: 121 TCNW Phones: 745-5997, 843-9028 (h)

Required Text

Genes and Signals by Mark Ptashne and Alexander Gann, Cold Springs Harbor Press, 2002.

ISBN 0-87969-633-8

Papers and Reviews listed in reading assignments below. (available from instructor)
 
 

Exams

There will be three exams given, each worth 100 points. Exams will be comprehensive over the material covered since the last exam.

Student Presentations

Each student will be required to present the contents of a journal article published within the last year that describes the advancement of knowledge in one of the areas of molecular genetics. The paper must be pre-approved by the instructor and a copy should be made available to the instructor by April 1. During the presentation the student should present sufficient background (perhaps out of other papers or reviews) so that the class will understand the nature of the question being answered and the general methods used to derive that answer. Each student will have 25 minutes for their presentation and the presentation will be worth 50 points. Points will be assigned for: thoroughness of the introduction, clear presentation of the purpose of the work presented in the paper, concise presentation of experimental evidence supporting the papers conclusions, a good summary of the conclusions and how they relate to the general body of knowledge in the field, and the demonstration of a thorough grasp of the subject as exhibited by the student's ability to answer questions (10 points for each area).

Point Summary:

Exam 1 100

Exam 2 100

Final Exam 100

Student Presentation 50

Total 350

Grades: A = 90-100%, B = 80-89.99%, C = 70-79.99%, D = 60-69.99%, F = 0 - 59.99%.

"Students with disabilities who require accommodations (academic adjustments and/or auxiliary aids or services) for this course must contact the Office for Student Disability Services, Room 445, Potter Hall. The OFSDS telephone number is (270) 745-5004 V/TDD. Please DO NOT request accommodations directly from the professor or instructor without a letter of accommodation from the Office for Student Disability Services."